National Heart, Lung, and Blood Institute 3R01HL161000-04S1

Mechanisms and interventions addressing accelerated cardiovascular disease risk in women with endometriosis

This award funds research investigating mechanisms and interventions to reduce accelerated cardiovascular disease risk in women with endometriosis, focusing on estrogen and LOX-1 receptor pathways and evaluating therapeutic interventions.

Description

Endometriosis is a debilitating estrogen-dependent gynecological disorder associated with chronic pelvic pain and a myriad of comorbidities associated with systemic inflammation including elevated cardiovascular disease (CVD) risk. We take an integrative physiology approach to examine the role of estrogens and LOX-1 receptor mechanisms mediating the increased CVD risk through parallel inflammatory mechanisms, and to examine two emerging interventions that have shown efficacy for reducing symptoms and long-term CVD risk in women with endometriosis. These studies have the potential to identify clinically relevant therapeutic targets and interventions to decrease CVD burden in women with endometriosis.

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