Award
National Institute of Biomedical Imaging and Bioengineering 1R21EB037898-01
Development of a Novel Biomarker and PET Radiotracer for Specific Imaging of Microglial Responses
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$618,670.00
Ceiling
$618,670.00
Awarded
July 30, 2025
Identifier
1R21EB037898-01
Award for developing a novel PET radiotracer to image microglial responses, targeting THIK-1, with applications in Alzheimer’s and multiple sclerosis research.
Description
The project focuses on developing PET radioligands targeting THIK-1 to image microglial responses in vivo. The research involves in vitro and in vivo evaluation using animal models of Alzheimer’s disease and multiple sclerosis. The project aims to provide critical information on the metabolism, efficacy, and safety of THIK-1 therapeutics. The proposal emphasizes innovation in targeting THIK-1 for neuroinflammation and neurodegeneration research.