Award
National Institute of Allergy and Infectious Diseases 5R01AI169850-04
Characterizing the role of LDL related receptor 1 (Lrp1) as host entry factor for multiple bunyaviruses
Recipient
Washington University, Saint Louis, MO
Award Amount
$767,375.00
Ceiling
$767,375.00
Awarded
April 08, 2026
Identifier
5R01AI169850-04
This NIH grant funds research to identify host factors for bunyavirus entry, focusing on Lrp1 as a key entry factor, to aid development of broad therapeutics against multiple bunyaviruses.
Description
Arthropod-transmitted viruses belonging to the large Bunyavirales order (such as Oropouche virus (OROV), La Crosse virus (LACV), and Rift Valley fever virus (RVFV)) can cause significant disease outbreaks in humans throughout the world. The proposed work aims to define critical host factors for virus entry, identify novel targets to facilitate pan-bunyavirus therapeutic development, and validate Lrp1 as a pan-bunyavirus entry factor. This research is crucial given the rising outbreaks, emerging nature of bunyaviruses, and their potential for bioterrorism.