Award
National Institute of General Medical Sciences 2R35GM138277-06
Decoding and Reprogramming Redox Signal Transduction Pathways
Recipient
University of Minnesota, Minneapolis, MN, United States
Award Amount
$423,500.00
Ceiling
$423,500.00
Awarded
March 12, 2026
Identifier
2R35GM138277-06
This NIH-funded research project aims to understand and reprogram cellular redox signaling pathways by studying specific enzymes and developing molecular tools, potentially leading to new therapeutic approaches for diseases related to redox imbalance.
Description
Research project focused on developing molecular strategies to control enzymatic redox circuitries in cells to address redox imbalances linked to diseases such as cancer and Alzheimer's. The project involves studying heme iron-based DosS and DosT enzymes, protein engineering, enzymology, spectroscopy, structural biology, and development of redox-selective activity-based probes.