National Institute of General Medical Sciences 1R35GM165492-01

Developing integrative tools to link nuclear structure to gene regulation in situ

Award to develop computational tools linking nuclear structure to gene regulation using spatial single-cell transcriptomics, with applications in various biological fields.

Description

This project aims to develop computational tools that integrate nuclear morphology and spatial single-cell transcriptomics to study how genomic instability and nuclear organization influence gene regulation. The project will create novel computational frameworks and proof-of-concept datasets, linking nuclear architecture with gene expression and genomic data, with broad applications in cancer biology, developmental biology, neuroscience, and environmental health.

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