Award
National Institute on Aging 5R01AG076783-05
Sialylation of TLR2 Induces Osteoclast Fusion and Th 17 differentiation During Aging
Recipient
Johns Hopkins University
Award Amount
$473,057.00
Ceiling
$473,057.00
Awarded
March 03, 2026
Identifier
5R01AG076783-05
Award for research on sialylation of TLR2 and its role in osteoclast fusion and Th17 differentiation during aging, aiming to develop treatments for rheumatoid arthritis.
Description
The project involves developing therapeutic treatments for rheumatoid arthritis using sialylation inhibitors. The project aims to characterize mechanisms of sialylated TLR2-induced osteoclast fusion and investigate the effect of sialylation on T cells at RA onset. The therapeutic effect of Soyasaponin Bb, a sialyltransferase inhibitor, will be examined.