Award
National Institute of Neurological Disorders and Stroke 1F32NS142584-01
Exploring the role of hippocampal hypervascularization in Rett syndrome pathogenesis
Recipient
Baylor College of Medicine, Houston, TX
Award Amount
$75,520.00
Ceiling
$75,520.00
Awarded
June 09, 2025
Identifier
1F32NS142584-01
Research project investigating the role of VEGF signaling in hippocampal vascular abnormalities and epilepsy development in Rett syndrome using molecular, electrophysiological, and imaging studies.
Description
This project aims to explore whether VEGF signaling drives hippocampal vascular abnormalities in Rett mice and if these contribute to epileptogenesis. Specific aims include evaluating VEGF and VEGFR2 expression, knocking down VEGF signaling, and using longitudinal imaging and pharmacological methods to assess the impact on epilepsy development.