Award
NIH Reporter #5R01HD060860-14
Adrenomedullin Signaling at the Maternal-Fetal Interface
Recipient
University of North Carolina at Chapel Hill, Department of Physiology
Award Amount
$419,055.00
Ceiling
$419,055.00
Awarded
January 07, 2026
Identifier
5R01HD060860-14
The award funds research on the role of adrenomedullin signaling in pregnancy, focusing on implantation and placental development, and its impact on pregnancy outcomes and complications.
Description
This project investigates how adrenomedullin (AM) signaling affects implantation and placentation, and how environmental factors influence AM levels and pregnancy outcomes, using genetic mouse models and cell assays. AM is involved in embryonic development, angiogenesis, cardio-protection, and innate immunity. Low maternal plasma AM levels are linked to pregnancy complications such as preeclampsia, fetal growth restriction, gestational diabetes, and spontaneous abortion. The project aims to understand the role of AM signaling in reproductive success and identify therapeutic targets.