Award
NIH Reporter #1F31MH144977-01
HIV-induced trained immunity in microglia and its contribution to HAND pathogenesis
Recipient
Drexel University, Philadelphia
Award Amount
$50,114.00
Ceiling
$50,114.00
Awarded
June 19, 2026
Identifier
1F31MH144977-01
Research project funded by NIH/NIMH to study HIV-1 effects on microglia and its role in HAND pathogenesis, using advanced molecular and metabolic assays.
Description
This project aims to define how HIV-1 reprograms microglia through maladaptive trained immunity, exploring epigenetic and metabolic mechanisms, and functional outcomes such as phagocytic capacity, ROS production, and microglia morphology. The research will utilize advanced techniques including chromatin immunoprecipitation and Seahorse metabolic assays.