Award
National Institute of General Medical Sciences 1R35GM163509-01
The Structure and Function of a Eukaryotic Centromere
Recipient
University of North Carolina at Chapel Hill
Award Amount
$528,497.00
Ceiling
$528,497.00
Awarded
July 29, 2026
Identifier
1R35GM163509-01
Research project funded by the National Institute of General Medical Sciences to study the physical structure and function of eukaryotic centromeres, using computational and bioimaging methods to understand chromosome segregation mechanisms.
Description
The project investigates the physical structure of centromere chromatin, focusing on the organization into a stiff spring that resists microtubule pulling forces during mitosis. It employs computational tools and bioimaging to explore the hypothesis that chromatin bottlebrushes organized by condensin and cohesin proteins generate tension between sister kinetochores.