Award
NIH Reporter #5R01CA262260-05
A stalled chromatin regulatory network that mediates the oncogenic activity of Meningioma-1
Recipient
CHILDREN'S HOSP OF PHILADELPHIA
Award Amount
$438,480.00
Ceiling
$438,480.00
Awarded
April 06, 2026
Identifier
5R01CA262260-05
Research grant awarded to study the molecular mechanism of MN1-mediated leukemic transformation to identify targeted therapy opportunities in acute myelocytic leukemia.
Description
High expression of the transcriptional co-activator Meningioma-1 (MN1) is common in AML, and associated with a poor prognosis. Forced expression of MN1 in murine hematopoietic progenitors induces an aggressive leukemia. Recent discoveries show MN1 stabilizes BAF on chromatin, maintaining active enhancer chromatin at sites regulating hematopoietic stem/progenitor programs. The project aims to uncover the molecular mechanism of MN1-mediated leukemic transformation to identify targeted therapy opportunities.