Award
National Institute of Allergy and Infectious Diseases 5R01AI168302-05
Mechanisms of Salmonella-mediated disruption of colonization resistance in the inflamed gut
Recipient
Vanderbilt University Medical Center
Award Amount
$489,526.00
Ceiling
$489,526.00
Awarded
July 17, 2026
Identifier
5R01AI168302-05
The project aims to elucidate how Salmonella Typhimurium-induced inflammation enables the pathogen to bypass colonization resistance by metabolizing microbiota-derived propionate and utilizing increased aspartate for fumarate respiration, promoting infection.
Description
This research investigates how Salmonella Typhimurium overcomes gut microbiota defenses during infection, focusing on inflammation-driven mechanisms such as fumarate and nitrate respiration, and the role of microbiota-derived metabolites like propionate and aspartate.