Award
NIH Reporter #RFA-AI-23-023
Adipocytes and inflammation in the cutaneous leishmaniasis outcome
Recipient
Federal University of Bahia
Award Amount
$120,226.00
Ceiling
$120,226.00
Awarded
July 28, 2026
Identifier
RFA-AI-23-023
Research project funded by NIAID to study the role of adipose tissue and obesity in the severity of cutaneous leishmaniasis, focusing on inflammatory responses and macrophage reprogramming for tissue repair.
Description
This project investigates the influence of adipose tissue and obesity on the severity of cutaneous leishmaniasis (CL). The hypothesis is that adipokines, lipid profiles, and leucocyte infiltration in adipose tissue are associated with inflammatory response-mediated tissue damage and disease severity. The study also explores how lipids can reprogram macrophages towards a wound healing phenotype.