Award
National Institute of General Medical Sciences 5R35GM149357-04
Mechanisms underlying chromosome segregation
Recipient
FRED HUTCHINSON CANCER CENTER
Award Amount
$352,000.00
Ceiling
$352,000.00
Awarded
July 08, 2026
Identifier
5R35GM149357-04
This award funds research to understand chromosome segregation mechanisms, particularly kinetochore assembly and attachments, to prevent aneuploidy-related diseases including cancer and birth defects.
Description
The study aims to understand the mechanisms of chromosome segregation, focusing on kinetochore assembly regulation and kinetochore-microtubule attachments, using yeast as a model. Accurate cell division is essential for development, and defects in chromosome partitioning cause aneuploidy, common in cancer cells and a factor in miscarriages and birth defects. The work is important for genomic stability and disease prevention.