Award
National Institute of Dental and Craniofacial Research 5R16DE034585-03
Fringe regulation of Notch signaling in osteoclasts
Recipient
Eastern Washington University, Cheney, WA, United States
Award Amount
$120,204.00
Ceiling
$120,204.00
Awarded
July 16, 2026
Identifier
5R16DE034585-03
Research funded by the National Institute of Dental and Craniofacial Research to investigate how Fringe-catalyzed glycosylation modulates Notch signaling in osteoclasts, with the goal of developing therapies to regulate osteoclast activity and prevent bone loss.
Description
This project studies the combinatorial effect of Fringe family glycosylation on Notch receptor activation and osteoclast formation and function, aiming to modulate Notch signaling intensity to influence osteoclast activity and prevent bone loss.