Award
National Institute of Neurological Disorders and Stroke 5K22NS118975-05
Innate Immunity Responses In Monocytes: Contribution To Neurodegeneration
Recipient
University of Puerto Rico Med Sciences
Award Amount
$213,923.00
Ceiling
$213,923.00
Awarded
August 11, 2025
Identifier
5K22NS118975-05
This award supports research on the role of innate immunity responses in monocytes contributing to neurodegeneration in Alzheimer's disease and HIV-associated neurocognitive disorders. The study investigates interferon signaling and insulin receptor biology in monocytes, using patient samples and brain organoid models, aiming to identify mechanisms and therapeutic targets for cognitive decline.
Description
Disruption of Innate Immunity Responses in Monocytes: Contribution to Neurodegeneration. Alzheimer's disease (AD) and HIV-associated neurocognitive disorders (HAND) involve monocyte recruitment to the brain affecting neurodegeneration. The study aims to characterize IFN-1 signaling and insulin receptor biology in monocytes from AD and HAND patients, determine monocyte effects in brain organoid models, and assess IFN-1 receptor modulation effects on macrophage phenotype and neuronal dysfunction. The research seeks to uncover mechanisms in neurodegenerative disorders and identify therapeutic targets.