Award
NIH Reporter #5R35GM158225-02
Understanding metabolic and regulatory control of antibiotic production in filamentous actinobacteria
Recipient
Washington University, Saint Louis, MO
Award Amount
$388,750.00
Ceiling
$388,750.00
Awarded
May 14, 2026
Identifier
5R35GM158225-02
Research project funded by the National Institute of General Medical Sciences to study metabolic and regulatory control of antibiotic production in filamentous actinobacteria, focusing on biosynthesis mechanisms and drug discovery enhancement.
Description
This project aims to investigate the metabolic and regulatory mechanisms controlling antibiotic production in filamentous actinobacteria. The research focuses on understanding how promoter polymorphisms, cellular ornithine status, and surface interactions influence the biosynthesis of bioactive molecules such as polycyclic tetramate macrolactams and piperazyl-peptides.