# NIH Reporter #1I01RD001314-01

Microbiota Transplant Therapy to Prevent HE Recurrence in a Phase 2B Multi-Center Trial of Veterans with Cirrhosis

**Recipient:** VA Veterans Administration Hospital

**Awarded:** October 30, 2026

**Identifier:** 1I01RD001314-01

The project will compare microbiota transplant therapy with placebo for preventing hepatic encephalopathy recurrence and assess related health outcomes, inflammation, microbiome changes, cognition, and quality of life.

### Description

A multicenter, double-blind, randomized, placebo-controlled clinical trial evaluating microbiota transplant therapy to prevent recurrent hepatic encephalopathy in Veterans with cirrhosis. The study plans to enroll 162 Veterans at VAMCs in Richmond, Dallas, and Connecticut, with six months of follow-up.

[View original record](https://reporter.nih.gov/search/7U_RDKopbE--cH-2OrGcnA/project-details/11299678)