Award
National Institute on Drug Abuse 5R01DA055414-05
Microglial pruning of dopamine receptors and opioid abuse.
Recipient
Duke University, Durham, NC, United States
Award Amount
$390,886.00
Ceiling
$390,886.00
Awarded
February 18, 2026
Identifier
5R01DA055414-05
This award funds research on how microglia prune dopamine receptors during adolescence and how this affects opioid abuse and reward behavior, with attention to sex differences.
Description
The project investigates the mechanisms of microglial pruning of dopamine receptors, its impact on reward processing, and differences between males and females, focusing on addiction, adolescent brain development, microglia, dopamine receptors, and opioid abuse.