Award
National Institute of Neurological Disorders and Stroke 5SC1NS127764-04
APE1 and Somatic Expansion in Huntington's Disease
Recipient
University of Puerto Rico Med Sciences, San Juan, PR, United States
Award Amount
$327,094.00
Ceiling
$327,094.00
Awarded
March 21, 2025
Identifier
5SC1NS127764-04
Research project funded by the National Institute of Neurological Disorders and Stroke to study the role of APE1 in delaying Huntington's Disease onset through mitochondrial DNA repair mechanisms.
Description
This project investigates the role of APE1, a key enzyme in mitochondrial DNA repair, as a genetic modifier that may delay Huntington's Disease onset by preventing mitochondrial DNA damage and somatic expansion. The research aims to elucidate the mechanistic functions of APE1 and mutant HTT in Huntington's Disease, potentially guiding future drug discovery.