Award
National Institute of General Medical Sciences 5R35GM138350-07
New Base-Promoted Oxidative and Reductive Coupling Reactions
Recipient
Colorado State University
Award Amount
$406,318.00
Ceiling
$406,318.00
Awarded
May 11, 2026
Identifier
5R35GM138350-07
This award funds research to develop new base-promoted oxidative and reductive coupling reactions to improve synthetic methods for drug discovery and production, focusing on efficient and versatile chemical reactions.
Description
The project aims to develop synthetic methods to improve access to chemicals needed for the discovery and production of new medicines. It focuses on inventing generalizable base-promoted reactions that address limitations in organic synthesis, including oxidative and reductive coupling reactions that combine nucleophiles or electrophiles. The methods involve using haloarenes as oxidants and activating disilanes to generate silyl anions, enabling new C–H bond and C–C bond-forming reactions. These reactions are designed to be more efficient, practical, and versatile than traditional methods, with applications in modifying bioactive molecules and synthesizing drug substructures.