Award
NIH Reporter #PA-23-272
Genetic and Environmental Sources of Heterogeneity in Alzheimer's Disease: A Pathway Specific Approach
Recipient
University of Pennsylvania
Award Amount
$49,538.00
Ceiling
$49,538.00
Awarded
August 15, 2025
Identifier
PA-23-272
NIH-funded project by University of Pennsylvania and NIA to study genetic and environmental factors in Alzheimer's Disease using polygenic risk scores, with a budget of approximately $49,538 for FY 2025, from September 2025 to August 2027.
Description
This NIH-funded project focuses on understanding the genetic and environmental heterogeneity in Alzheimer's Disease through innovative polygenic risk score methods and gene-environment interaction analysis. The project aims to explore novel methods in polygenic risk score construction and investigate gene-environment interactions in Alzheimer's Disease. It involves constructing pathway-specific polygenic risk scores and assessing their predictive performance across different levels of environmental exposure, with the goal to identify druggable targets and high-risk groups for Alzheimer's Disease.