National Institute on Alcohol Abuse and Alcoholism 5P60AA032176-02

Alcohol, Gut derived inflammation, Disturbed Tryptophan Metabolism and CVD risk in People With HIV (GUT CVD HIV)

The award funds research on how heavy alcohol use and HIV infection together increase cardiovascular disease risk in people with HIV by affecting tryptophan metabolism and immune responses, using existing cohorts and testing probiotic interventions.

Description

This project investigates the interactive effects of heavy alcohol use and HIV-1 infection on cardiovascular disease (CVD) risk in people living with HIV (PWH). It focuses on gut-derived inflammation, disturbed tryptophan metabolism, and the resultant increase in inflammatory kynurenine pathway metabolites that may exacerbate CVD. The study leverages two existing cohorts to assess the relationship between alcohol consumption, tryptophan catabolism, immune cell changes, and CVD risk, and evaluates the impact of probiotic administration.

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