Award
National Institute of General Medical Sciences 1R15GM159330-01
Evolution of pleiotropic consequences via mucoid phage resistance in Escherichia coli populations
Recipient
University of Wisconsin Milwaukee
Award Amount
$572,553.00
Ceiling
$572,553.00
Awarded
August 28, 2025
Identifier
1R15GM159330-01
Research project funded to study the evolution of mucoid phage resistance in E. coli and its pleiotropic effects on bacterial virulence and antibiotic resistance.
Description
This project investigates the impact of lytic bacteriophage on bacterial virulence and antibiotic-resistance factors, focusing on the evolution of mucoidy-based phage resistance in Escherichia coli. The study aims to understand how genetic and environmental factors constrain bacterial resistance mechanisms and how these insights can be used to steer bacterial populations toward less pathogenic states.