Award
National Institute of General Medical Sciences 5R35GM148239-04
Chemical biology of voltage-gated cation channels
Recipient
University of Iowa
Award Amount
$614,225.00
Ceiling
$614,225.00
Awarded
January 19, 2026
Identifier
5R35GM148239-04
Award for research on voltage-gated cation channels using chemical biology to understand channel function and drug interactions, supporting treatments for various diseases.
Description
The project aims to provide training opportunities and advance understanding of voltage-gated ion channels using chemical biological approaches. The project involves high-resolution structural studies, development of photochemical stapling approaches, and investigation of channel gating mechanisms. The research will contribute to understanding drug binding modes and channel function, with implications for treating pain, epilepsy, arrhythmia, and heart failure.