Award
National Institute on Aging 3R01AG079217-05S1
Targeting Microglial Lipoprotein Lipase in Alzheimer's disease
Recipient
University of Colorado Denver
Award Amount
$15,467.00
Ceiling
$15,467.00
Awarded
June 22, 2026
Identifier
3R01AG079217-05S1
The project investigates lipoprotein lipase in microglia as a therapeutic target for Alzheimer's disease, aiming to enhance LPL activity to clear amyloid-beta and slow disease progression.
Description
This project aims to investigate the role of lipoprotein lipase (LPL) in microglia as a therapeutic target for Alzheimer's disease (AD). The research will use microglial-specific knockdown mice and AD susceptible mice to evaluate whether pharmacological activation of LPL can halt AD progression. The study will also analyze LPL-dependent mechanisms controlling microglial metabolism and function, and assess whether enhancing LPL activity can restore lipid handling in APOE4 carriers.