NIH Reporter #5I01BX003648-08

Vitamin D and Development Origins of Obesity and Insulin Resistance

A research project funded by the Veterans Affairs to study how vitamin D deficiency in utero affects obesity and insulin resistance development, aiming to identify mechanisms and potential preventive vitamin D supplementation during pregnancy.

Description

This NIH grant project focuses on investigating the role of vitamin D deficiency during pregnancy in programming obesity and insulin resistance in offspring. The study explores genetic and epigenetic mechanisms, including immune cell programming and adipose tissue differentiation, and evaluates the effects of antenatal vitamin D supplementation to reduce obesity and insulin resistance risk. The research involves clinical trials, animal models, and molecular analyses.

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