Award
National Institute on Aging 1R01AG092662-01
Multiscale Modeling of Hippocampus Vulnerability to Alzheimer's Disease Neurodegeneration
Recipient
University of Southern California
Award Amount
$695,789.00
Ceiling
$695,789.00
Awarded
December 29, 2025
Identifier
1R01AG092662-01
This NIH-funded project develops a computational model to study hippocampal vulnerability in Alzheimer's disease, aiming to simulate network disconnection and support therapeutic development.
Description
The project aims to develop a multiscale computational model (HGEA-NET) of the hippocampus to understand how neurodegeneration in Alzheimer's disease (AD) leads to cognitive decline. Building on the Hippocampus Gene Expression Atlas (HGEA), the team will incorporate spatial transcriptomics and connectomics data from human AD patients and mouse models to identify susceptible neurons and simulate network disconnection.