Award
National Institute of Diabetes and Digestive and Kidney Diseases 1R01DK142433-01
Mitoprotective therapies for kidney injury
Recipient
University of Tennessee Health Science Center, Memphis, TN
Award Amount
$3,010,432.00
Ceiling
$3,010,432.00
Awarded
September 11, 2025
Identifier
1R01DK142433-01
Development and testing of small molecule compounds to stabilize mitochondrial function and prevent acute kidney injury by targeting mitochondrial proteins.
Description
This project aims to develop and test novel small molecule compounds that stabilize mitochondrial function to mitigate kidney injury, specifically acute kidney injury (AKI). The research focuses on targeting mitochondrial proteins such as Phospholipid Scramblase 3 (PLSCR3) with pharmacological agents like AB-3 and Belumosudil to prevent RTEC cell death and improve renal outcomes.