Award
NIH Reporter #1R35GM161279-01
The role of the nuclear pore complex in spatially organizing the genome and regulating gene expression
Recipient
Northwestern University, Chicago, IL
Award Amount
$598,848.00
Ceiling
$598,848.00
Awarded
September 09, 2026
Identifier
1R35GM161279-01
This award funds research to understand how the nuclear pore complex influences gene expression and epigenetic regulation by mediating genome interactions, with studies in yeast and humans.
Description
Understanding the molecular control of transcriptional responses of cells to environmental signals is essential to understand how environment, aging, and lifestyle impact physiology. The research focuses on how genomes associate with the nuclear pore complex (NPC), mediated by transcription factors, influencing gene expression and epigenetic regulation. The work aims to test findings in yeast and humans to elucidate how the NPC impacts gene expression.