Award
National Institute of General Medical Sciences 5P20GM109097-10
Cumulative Effect of ACEs on the Neurocircuitry of Drug Withdrawal
Recipient
OSU CENTER FOR HEALTH SCIENCES, TULSA, OK, UNITED STATES
Award Amount
$259,645.00
Ceiling
$259,645.00
Awarded
July 10, 2026
Identifier
5P20GM109097-10
Research project studying the impact of childhood adversity on brain mechanisms related to nicotine withdrawal in ENDS users, aiming to inform treatments for substance use disorders.
Description
The proposed project examines how cumulative Adverse Childhood Experiences (ACEs) influence the brain mechanisms underlying nicotine withdrawal symptoms, specifically cognitive control and craving sensations, in users of Electronic Nicotine Delivery Systems (ENDS). The study involves neuroimaging, behavioral assessments, and biochemical measures to understand the impact of childhood adversity on nicotine withdrawal mechanisms.