Award
NIH Reporter #5R01ES033056-05
Gut-brain dysfunction following combined prenatal stressors: relevance for autism
Recipient
Duke University, Durham, NC
Award Amount
$347,255.00
Ceiling
$347,255.00
Awarded
January 15, 2025
Identifier
5R01ES033056-05
NIH awarded a grant to Duke University to study how prenatal exposure to air pollution and maternal stress affects gut microbiome and autism-like behaviors in mice, aiming to find therapeutic intervention windows.
Description
This NIH grant project investigates the impact of prenatal diesel exhaust particle exposure combined with maternal stress on gut microbiome development and autism-like behaviors in mice. The study aims to characterize microbiome changes, establish causality with behavioral abnormalities, and identify critical intervention windows to advance understanding of gut dysbiosis and brain dysfunction in autism.