# NIH Reporter #5R01DA059310-04

Microglial modulation of neurocircuits in HIV/cocaine comorbidity

**Recipient:** University of South Carolina at Columbia

**Award Amount:** $508,540.00
**Ceiling:** $508,540.00

**Awarded:** November 04, 2026

**Identifier:** 5R01DA059310-04

The project studies how HIV and prior psychostimulant use may interact to disrupt microglial function and fronto-striatal circuitry, contributing to neurocognitive decline.

### Description

Research project investigating how HIV infection and a history of cocaine or other psychostimulant use affect microglial function, dendritic spines, neurocircuits, and neurocognitive outcomes.

[View original record](https://reporter.nih.gov/search/a_XEnEpPR0i-06zXlbqcPw/project-details/11468420)