Award
NIH Reporter #5DP2AI171122-05
Parallel phenotyping to dissect genetic determinants of bacterial strain diversity
Recipient
Utah State Higher Education System--University of Utah, Salt Lake City, UT
Award Amount
$448,018.00
Ceiling
$448,018.00
Awarded
July 21, 2026
Identifier
5DP2AI171122-05
The project develops a molecular barcoding approach for parallel fitness phenotyping of bacterial isolates, focusing on Mycobacterium avium to elucidate genetic determinants of pathogenicity and antibiotic response, informing diagnostics and therapeutics.
Description
This project aims to use novel genetic tools to identify bacterial genes that enable some strains of Mycobacterium avium to establish chronic infection and tolerate prolonged antibiotic exposure. The work will provide insights into bacterial evolution into pathogens and support the development of improved therapies for chronic bacterial infections.