Award
National Cancer Institute 1DP2CA311215-01
Genetic Engineering of Myeloid Cells to Treat Cancer
Recipient
University of California, San Francisco
Award Amount
$1,476,000.00
Ceiling
$1,476,000.00
Awarded
July 31, 2025
Identifier
1DP2CA311215-01
NIH/NCI funded research project at University of California, San Francisco to genetically engineer myeloid cells for cancer therapy, focusing on solid tumors using advanced genetic tools and synthetic receptors.
Description
This project aims to use innovative engineering strategies to harness the innate immune system by genetically engineering myeloid cells to create living medicines capable of effectively combating solid tumors. The project involves CRISPR gene editing, synthetic receptor library design, and in vivo engineering to enhance tumoricidal activities and resistance to immunosuppression.