Award
National Institute of Allergy and Infectious Diseases 3R01AI169893-04S1
Reprogramming of tissue structural cells by cutaneous CD4+ T cells
Recipient
Benaroya Research Institute at Virginia Mason
Award Amount
$174,987.00
Ceiling
$174,987.00
Awarded
May 25, 2026
Identifier
3R01AI169893-04S1
The NIH grant supports research on how cutaneous CD4+ T cells reprogram tissue structural cells to influence inflammatory memory in skin, aiming to develop therapies for inflammatory skin diseases.
Description
This project aims to investigate how T cells influence inflammatory memory in the skin, focusing on the cross-talk between T cell cytokines and structural cells in vitro, in murine models, and in patient samples. The goal is to understand the reprogramming of keratinocytes and fibroblasts during inflammation and to explore therapeutic strategies to reset inflammatory memory and break the cycle of skin inflammation.