NIH Reporter #5DP2AI177896-04

Deciphering long-term virus evolution through the reconstruction of past viral genomes

The award supports research to reconstruct ancient viral genomes to understand long-term virus evolution and origins of pathogenic RNA viruses, enhancing knowledge to combat viral diseases.

Description

This project aims to identify and analyze ancient viral genomes to better understand viral evolution and improve future pandemic preparedness. It seeks to uncover viral diversity during historical epidemic outbreaks, reconstruct viral genomes from human remains and preserved lung specimens, and study the origins and evolution of highly pathogenic RNA viruses over the past ~500 years.

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