Award
National Institute of Allergy and Infectious Diseases 1R01AI198969-01
ZBP1 signaling in RSV triggered host defense and pathogenesis
Recipient
Washington State University, Pullman, WA, United States
Award Amount
$618,650.00
Ceiling
$618,650.00
Awarded
August 05, 2026
Identifier
1R01AI198969-01
The award supports research on the role of ZBP1 in RSV-induced cell death pathways and lung injury, with the goal of developing therapies using a RIPK3 inhibitor.
Description
This project investigates how RSV activates ZBP1 to induce necroptosis and pyroptosis, contributing to lung injury and disease. It aims to study the role of ZBP1-mediated cell death in immunity and host defense, and to test a RIPK3 kinase inhibitor as a therapeutic strategy for RSV-induced respiratory disease.