Award
NIH Reporter #1RF1NS148618-01
Mechanisms of Fibrinogen-Mediated Cerebrovascular Pathology in Cerebral Amyloid Angiopathy
Recipient
Rutgers Biomedical and Health Sciences, Newark, NJ, United States
Award Amount
$1,872,632.00
Ceiling
$1,872,632.00
Awarded
August 31, 2026
Identifier
1RF1NS148618-01
Research project funded by NINDS to study the role of fibrinogen and caveolae-mediated transcytosis in Cerebral Amyloid Angiopathy, particularly how APOE4 genotype influences disease progression and vascular pathology in Alzheimer's disease.
Description
This interdisciplinary research aims to elucidate the molecular mechanisms underlying Cerebral Amyloid Angiopathy (CAA), a major cerebrovascular pathology in Alzheimer’s disease (AD) that affects over 80% of AD patients. The study investigates how fibrinogen and caveolae-mediated transcytosis contribute to CAA development, focusing on the impact of APOE4 genotype on disease progression and potential therapeutic targets.