Award
National Institute of Allergy and Infectious Diseases 5U19AI174994-04
Oklahoma C. difficile U19 Challenge Core
Recipient
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Award Amount
$76,676.00
Ceiling
$76,676.00
Awarded
June 30, 2026
Identifier
5U19AI174994-04
This award funds the development of a standardized 'Challenge Core' to test vaccine efficacy against C. difficile using animal models, supporting multiple research projects and ensuring experimental rigor.
Description
The Oklahoma C. difficile U19 program aims to develop a second-generation vaccine for C. difficile by understanding mechanisms that limit vaccine responses. The project involves standardizing challenge experiments using relevant animal models (murine, hamster) to test vaccine efficacy. A dedicated 'Challenge Core' will provide standardized services, including developing and optimizing challenge models, to facilitate rigorous and reproducible research.