Award
National Institute of Allergy and Infectious Diseases 5R01AI168178-05
Structural interrogation of vaccine- and infection-induced B cell responses
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY
Award Amount
$780,825.00
Ceiling
$780,825.00
Awarded
January 06, 2026
Identifier
5R01AI168178-05
A research project funded by NIAID to study immune imprinting and antibody protection against viruses such as SARS-CoV-2 using structural biology techniques.
Description
This project aims to understand the structural features of immune imprinting and the correlates of antibody protection against viruses like SARS-CoV-2. Using structural biology approaches, primarily cryo-EM, the study will map antibody epitopes on protein structures, analyze immune responses longitudinally, and investigate how pre-existing immunity influences vaccine responses and viral escape.