Award
National Institute on Aging 1R21AG099044-01
Pilot of a new non-viral vector for therapeutic nucleic acid delivery to the CNS
Recipient
Massachusetts Institute of Technology, Cambridge, MA, United States
Award Amount
$466,340.00
Ceiling
$466,340.00
Awarded
January 21, 2026
Identifier
1R21AG099044-01
A multiyear research project funded by the National Institute on Aging to develop a novel non-viral vector for delivering therapeutic nucleic acids to the central nervous system to treat Alzheimer's Disease.
Description
This project aims to develop a non-viral delivery platform using nucleic acid nanoparticles (NANPs) to target specific regions and cell types in the CNS after intrathecal administration, delivering therapeutic siRNAs and mRNAs for Alzheimer's Disease treatment.