Award
National Institute of Allergy and Infectious Diseases 5K08AI183990-03
ENHANCEMENT OF CD4CAR T-CELL PERSISTENCE IN VIVO
Recipient
University of Washington
Award Amount
$186,408.00
Ceiling
$186,408.00
Awarded
July 20, 2026
Identifier
5K08AI183990-03
The award supports research to enhance the persistence and efficacy of HIV-targeting CD4CAR T cells to achieve viral remission without antiretroviral therapy, focusing on overcoming soluble antigen inhibition, enhancing persistence with IL-15, and validating in primate models.
Description
This project aims to develop HIV-targeting CAR T cells with enhanced long-term persistence to achieve viral remission without ART. It involves advancing HIV-targeting chimeric antigen receptor (CAR) T cells, specifically CD4CAR T cells, to improve their persistence and efficacy in vivo, including characterizing the effects of soluble antigen on CAR T-cell function, extending T-cell persistence with IL-15 cytokine, and validating strategies in non-human primate models.