Award
National Heart, Lung, and Blood Institute 7R01HL163820-04
A redox-sensitive switch in the macrophage nucleus regulates acute phase inflammatory injury
Recipient
H. LEE MOFFITT CANCER CTR & RES INST, TAMPA, FL, UNITED STATES
Award Amount
$613,814.00
Ceiling
$613,814.00
Awarded
July 23, 2025
Identifier
7R01HL163820-04
NIH grant awarded to study how nuclear reactive oxygen species in macrophages regulate inflammation and ARDS risk, aiming to develop therapeutic strategies to mitigate lung injury.
Description
This project investigates the role of reactive oxygen species (ROS) produced in the nucleus of macrophages in regulating inflammation and the transition to resolution phase, with implications for preventing Acute Respiratory Distress Syndrome (ARDS). The research hypothesizes that oxidative stress in the nucleus mimics nitric oxide (NO) effects, extending inflammation and increasing ARDS risk in vulnerable populations such as the elderly, smokers, and those with metabolic conditions.