Award
NIH Reporter #5K23HD115837-03
Oxytocin-mediated calcium signaling in physiologic uterine contractility and uterine atony
Recipient
Stanford University
Award Amount
$165,672.00
Ceiling
$165,672.00
Awarded
June 05, 2026
Identifier
5K23HD115837-03
Research project funded by NICHD to study uterine contractility and uterine atony mechanisms, focusing on TRPV4 channel and oxytocin interaction, aiming to develop new treatments for postpartum hemorrhage.
Description
This project aims to provide insights into how the uterus contracts after delivery and what goes wrong in uterine atony, potentially facilitating the development of new treatments. The research will investigate the cellular and molecular mechanisms of human uterine contractility, focusing on the role of the TRPV4 channel and its activation pathways. The study involves translational research using uterine tissue and smooth muscle cell cultures from women with normal contractility and uterine atony.