Award
National Heart, Lung, and Blood Institute 5R01HL088256-15
Vesicular trafficking mechanisms regulating granulocyte function
Recipient
SCRIPPS RESEARCH INSTITUTE, THE, LA JOLLA, CA, UNITED STATES
Award Amount
$727,183.00
Ceiling
$727,183.00
Awarded
August 15, 2025
Identifier
5R01HL088256-15
NIH grant awarded to Scripps Research Institute to study vesicular trafficking in neutrophils, focusing on mechanisms regulating vesicular transport and neutrophil functions in inflammation and infection models.
Description
This project aims to elucidate the molecular mechanisms regulating vesicular transport associated with exocytosis, phagocytosis, late endosomal maturation, and NETs production in neutrophils. The research involves innovative quantitative methods and small-molecule inhibitors to investigate vesicular transport mechanisms and neutrophil functions in disease models of systemic inflammation and infection.