Award
NIH Reporter #5P01AI191224-02
Project 2 - Development of HLA-E-peptide antibodies for enhancing NK and CD8 killing of HIV infected CD4 T cells in vivo
Recipient
University of Alabama at Birmingham, Birmingham, AL, United States
Award Amount
$1,094,343.00
Ceiling
$1,094,343.00
Awarded
August 24, 2026
Identifier
5P01AI191224-02
The award supports the development of high-affinity antibodies against HLA-E-peptide complexes to boost NK and CD8 T cell activity against HIV-infected cells, using advanced design and evaluation methods.
Description
This project aims to develop high-affinity antibodies targeting HLA-E-peptide complexes to enhance immune responses against HIV-infected cells, leveraging structure-based design, AI modeling, and cellular assays.