Award
National Institute on Aging 5R01AG048923-09
Characterization of ApoE4 Induced Phospholipid Dysregulation in AD Pathogenesis
Recipient
University of Minnesota
Award Amount
$648,233.00
Ceiling
$648,233.00
Awarded
March 27, 2025
Identifier
5R01AG048923-09
This award supports research to characterize how APOE4 affects phospholipid regulation and microglial function in Alzheimer's disease, aiming to understand molecular mechanisms and identify therapeutic targets.
Description
The project focuses on the role of APOE4 in Alzheimer's disease, specifically on microglial function and neuroinflammation. The research involves in vivo mouse models, ex vivo microglial cultures, and human brain sample validation. The study aims to elucidate molecular pathways and signatures for targeted therapies.