Award
National Institute of Dental and Craniofacial Research 5R01DE027538-09
Cell lineage and transcriptional analysis of the vertebrate neural plate border
Recipient
California Institute of Technology, Pasadena, CA, United States
Award Amount
$540,386.00
Ceiling
$540,386.00
Awarded
December 05, 2025
Identifier
5R01DE027538-09
A multi-year NIH research grant awarded to study gene regulation and development of neural crest and placode cells, focusing on pluripotency factors and enhancer analysis.
Description
This project aims to investigate the transcriptional events underlying the formation of neural crest and ectodermal placode cells from the neural plate border. It focuses on the role of pluripotency factors such as Sall4, Nanog, Oct4, Klf4, and cMyc in maintaining multipotency and their regulation during neural crest and placode development.