Award
National Heart, Lung, and Blood Institute 5R01HL155948-05
Role of MIF and CD74 in the pathogenesis of emphysema
Recipient
Yale University, New Haven, CT
Award Amount
$684,815.00
Ceiling
$684,815.00
Awarded
January 03, 2025
Identifier
5R01HL155948-05
This NIH grant funds research on the protective role of MIF and its receptor CD74 in emphysema, aiming to uncover therapeutic targets by studying cellular senescence pathways.
Description
The project investigates how the innate immune protein MIF protects against emphysema, focusing on its receptor CD74 and cellular senescence pathways. The research aims to define mechanisms by which MIF mitigates endothelial senescence and to explore therapeutic potential targeting MIF-CD74 interactions.